To investigate the relationship between lncRNA NUTM2A-AS1 and miR-376a-3p in glioma, we transfected control-siRNA, lncRNA NUTM2A-AS1-siRNA, inhibitor control, miR-376a-3p inhibitor, lncRNA NUTM2A-AS1-siRNA + inhibitor control or lncRNA NUTM2A-AS1-siRNA + miR-376a-3p inhibitor into U251 and A172 cells. The gene discussed is NUTM2A; the disease is glioma.