Bansal et al. showed that the administration of 2 doses of IP ghrelin (20 μg/kg total) right before and after severe WD TBI preserved intestinal barrier integrity, restored villous architecture and reduced ileal levels of TNF-α [171].They also demonstrated that the beneficial effects of vagus nerve stimulation (VNS) following TBI may be mediated through ghrelin [172, 173]. Here, GHRL is linked to Wilson disease.