While ∼ 50% of the genes (e.g., Npg, Camp, Ltf, Chil3, Cd177) showing high-level expression in these early-stage leukemia related MDSC, have also been reported in MDSC in other setting, such as lung cancer [45], the remaining 50% appear to be unique to the SCLL TME (e.g., Erg, Capg, Golim4, Cd55, Trp53inp2). This evidence concerns the gene OPA1 and leukemia.