Of the upregulated genes (Fig. 4D), Syne1, Atxn10 and Dach1 show activation as early as Day 11, while Ngp, Abca13, Adpgk, Mmp8 and Lcn2 were more significantly upregulated in the later stage, D14 neutrophils,which suggests a sequential activation in Camk1d + neutrophils during leukemia progression. Here, LCN2 is linked to leukemia.