Among them, the NOTCH2 gene was related to cell stemness [24], which could induce and regulate the occurrence and apoptosis of tumor cells; NT5E could inhibit the growth, EMT process, and AKT/GSK-3β signaling pathway of sunitinib-resistant cells in renal cell carcinoma [25]. The gene discussed is NOTCH2; the disease is hereditary clear cell renal cell carcinoma.