The cumulative incidence of IHD and CVD death increased stepwise from individuals with no type 2 diabetes and CRP < 2 mg/L, through individuals with no type 2 diabetes and a CRP ≥ 2 mg/L, individuals with type 2 diabetes and a CRP < 2 mg/L, and to individuals with both type 2 diabetes and a CRP ≥ 2 mg/L (p for trend = 2 × 10− 56 and 2 × 10− 20). The gene discussed is CRP; the disease is myocardial ischemia.