To determine the association of HF-related parameters with the patchiness phenotype, Pearson correlation analysis was performed, showing correlation coefficients R2 of 0.9362 (P < 0.0001), 0.7832 (P < 0.0001), 0.7237 (P < 0.0001), and 0.7333 (P < 0.0001) between the primary HF diameter, secondary HF diameter, dermal layer thickness, epidermal layer thickness, and KRT82 mRNA expression, respectively (Fig. 3). The gene discussed is KRT82; the disease is hydrops fetalis.