Bioinformatics analysis predicted that rabbit KRT82 is an unstable and hydrophilic protein and its overexpression or knockdown in DPCs could have important consequences on the expression of genes associated with growth and development in the skin and HF, such as SFRP2 [31], TGFβ1 [32], WIF1 [33], BCL2 [34], CCND1 [35], LEF1 [36], CTNNB1 [37], and EGF [38], indicating that KRT82 plays an important role in the regulation of skin and HF development. The gene discussed is LEF1; the disease is hydrops fetalis.