Dietary fiber could also mitigate hepatic steatosis via the liver’s G-protein-coupled receptor (GPR) 41/43-calmodulin-dependent protein kinase II (CaMKII), histone deacetylase 1 (HDAC1)-cyclic adenosine monophosphate response element-binding protein (CREB) pathway [37]. This evidence concerns the gene HDAC1 and fatty liver disease.