In chronic kidney disease (CKD), the disturbance of the fibroblast growth factor 23 (FGF23) /1,25-dihydroxyvitamin D [1,25 (OH)2D]/ parathormone (PTH) axis and the irregulation of calcium and phosphate jointly lead to decreased bone mass and increased fragility fractures [48]. This evidence concerns the gene FGF23 and chronic kidney disease.