At a mechanistic level, K17 has also been reported to impact the pathogenesis of cervical squamous cell carcinoma, at least in part via immunomodulatory mechanisms [59] and others have explored mechanisms through which K17 might regulate resistance to immunotherapy, through the regulation of Yap1 activation, mediating downstream immunosuppressive effects in head and neck cancer. The gene discussed is KRT17; the disease is head and neck cancer.