Apart from IL-1b and IL-18, we also noted other suggestive causal associations between systemic inflammatory regulators and CKD or kidney function, including bNGF, GROa, IL-7 and SCGFb with CKD, MIP1b and TRAIL with BUN and IL-2ra, IL-4, MIG and MIP1b with eGFRcrea. This evidence concerns the gene CCL4 and chronic kidney disease.