Meanwhile, in the reverse MR analyses, genetically liability to CKD and kidney function was significantly associated with the concentrations of 4 systemic inflammatory regulators, including CKD, eGFRcys with GCSF, CKD, eGFRcrea with SCF, eGFRcys with IFNg and eGFRcys with VEGF. Here, IFNG is linked to chronic kidney disease.