Our findings revealed that genetically predicted levels of 11 systemic inflammatory regulators showed potential evidence of MR effects on CKD and kidney function in the forward MR analyses, including bNGF, GROa, IL-7 and SCGFb for CKD, IL-18, MIP1b and TRAIL for BUN, IL-2ra, IL-4, MIG and MIP1b for eGFRcrea and IL-1b for eGFRcys. Here, TNFSF10 is linked to chronic kidney disease.