Higher genetically predicted beta-nerve growth factor (bNGF) (IVW OR = 1.074; 95% CI, 1.005–1.148; P = 0.036), growth-regulated protein alpha (GROa) (IVW OR = 1.035; 95% CI, 1.003–1.067; P = 0.029), IL-7 (IVW OR = 1.044; 95% CI, 1.004–1.086; P = 0.032) and stem cell growth factor beta (SCGFb) (IVW OR = 1.053; 95% CI, 1.008-1.100; P = 0.021) were associated with increased risk of CKD. The gene discussed is CXCL1; the disease is chronic kidney disease.