Genetically determined CKD was related to the concentration of IL-17 (IVW OR = 1.134; 95% CI, 1.022–1.258; P = 0.025), which was a pro-inflammatory cytokine secreted by a distinct type of T cells, T helper cells and certain other lymphocytes and mainly involved in inflammatory and autoimmune diseases, such as psoriatic arthritis, ankylosing spondylitis and psoriasis [36, 40]. The gene discussed is IL17A; the disease is chronic kidney disease.