Meanwhile, in the reverse MR analyses, genetically liability to CKD and kidney function was significantly associated with the concentrations of 4 systemic inflammatory regulators, including CKD, eGFRcys with GCSF, CKD, eGFRcrea with SCF, eGFRcys with IFNg and eGFRcys with VEGF. The gene discussed is VEGFA; the disease is chronic kidney disease.