MYC and cancer: The oncogene MYC, also known as c-MYC, belongs to a family of genes whose protein products are frequently overactivated in human cancers.14 As a transcription factor regulating thousands of genes directly or indirectly, MYC is a master controller of multiple biological programs.15,16 In addition to its cell-intrinsic effects, MYC also influences host immunity and the tumor microenvironment.17 Numerous studies have shown that MYC overexpression can cause cancer.