CD274 and neoplasm: MYC regulation of PD-L1 expression directly participates in MYC-driven tumorigenesis initiation and continuation.17 MYC overexpression may constitute a general mechanism whereby tumor cells upregulate immune checkpoint regulator expression, thereby circumventing immune surveillance.17 MYC inactivation has been proposed to reinstate antitumor immune responses.23,24 However, no drug has yet demonstrated effective therapeutic targeting of MYC or its pathway, although promising candidates are in development.25