Reculstering of IFNγ pathway genes showed a shifted expression profile in the IFNγ pathway in sh61A CAL 27 cells, with pronounced downregulation of CD274 and CD47 (Fig. 6a), reinforcing the conclusion that TRMT61A is critical to the reactive upregulation of PD-L1 on cancer cells during inflammation. Here, TRMT61A is linked to cancer.