Cancer requires multiple genetic events and the acquisition of hallmarks of cancer.31 Importantly, MYC activation can contribute to many hallmarks, including proliferation, self-renewal, survival, genomic instability, metabolism, invasiveness, angiogenesis, and immune evasion.25 High-throughput sequencing of shCtrl and sh61A HNSCC cells revealed differentially expressed genes (Figs. S7a, S8a). The gene discussed is MYC; the disease is cancer.