For example, transgenic MYC overexpression in mice was sufficient to cause B-cell lymphoma.18 Additional research confirmed MYC’s ability to induce various cancer types in humans.19,20 MYC-induced tumors regressed rapidly and dramatically when MYC was inactivated in mouse models, even without affecting normal endogenous MYC.21,22 This phenomenon, called oncogene addiction, suggests targeting MYC could effectively treat some human cancers. Here, MYC is linked to B-cell non-Hodgkin lymphoma.