Mice were either implanted with murine mesothelin-expressing PDA7940b, an immunologically “cold” murine pancreatic ductal adenocarcinoma (PDA) cell line derived from KPC (KrasLSL.G12D/+p53R172H/+) mice, or with B16-F10 transduced with human CD19 (B16-huCD19) (Supplementary Fig. 1a). Here, CD19 is linked to pancreatic ductal adenocarcinoma.