The mRNA production of IFNβ and ISGs (ISG56, MX1, and IFIT2) was then measured in PBMCs from individuals carrying the WWP2 p.R841H variant (patient with HSE and 3 family members) and from controls (patient’s father and 7 unrelated individuals) after stimulation with Poly(I:C). The gene discussed is WWP2; the disease is herpes simplex encephalitis.