Subsequently, excessive iron promoted the generation of reactive oxygen species (ROS) through iron-dependent Fenton reactions and the activation of iron-containing enzymes, which further induced lipid peroxidation and lipid membrane rupture, triggering and activating ferroptosis, thereby enhancing chemotherapy sensitivity.p53 is an important tumor suppressor gene, and direct or indirect intervention with p53 has a good anti-tumor effect45. The gene discussed is TP53; the disease is neoplasm.