C1S and posterior cortical atrophy: Among the ten identified hub genes, GOLGA8B was found to be upregulated (P < 0.0001) in PCa tissues, whereas ITGB1, CLIP4, MAP1B, CXCL1, C1S, and CXCL6 exhibited downregulation upon PCa onset (P < 0.05; Fig. 3A).