This substantial ACE2 overexpression in SH-ACE2 corresponded with a significantly higher viral load, reaching 1.1X108 PFU/mL at 24 h post-infection, representing a 4-log increase when compared to SH-SY5Y (Fig. 5C, One-way ANOVA, F9,39 = 123.4, p < 0.0001). Here, ACE2 is linked to infection.