PARP1 and neoplasm: Although no direct evidence has been provided for a direct link between Parthanatos and extracellular matrix remodelling, session the importance of PARP-1 activation in the regulation of cell fate, and the fact that the process of ECM remodelling in tumour progression and inflammatory response is often accompanied by cell death and alterations in nuclear activity [28, 29], it can be speculated that Parthanatos-associated miRNAs may indirectly promote ECM remodelling by affecting these nuclear proteases and related cell death pathways.