Moreover, while control tumors (7/7) displayed anaplastic features typical of aggressive ccRCC (Elias et al, 2021), including large areas of sarcomatoid or rhabdoid differentiation (Fig. 3G), PML-depleted tumors conserved a distinctive eosinophilic clear-cell morphology (7/7) and showed signs of remission in some cases (2/7 were small masses characterized by few tumor cells embedded in fibrotic tissue; Fig. 3G). The gene discussed is PML; the disease is nonpapillary renal cell carcinoma.