PML and Familial prostate cancer: For example, PML inhibits cholesterol biosynthetic pathways also in prostate cancer (Chen et al, 2018), but in apparent contrast with our observations PML promotes the expression of extracellular matrix (ECM) remodeling factors in TNBC (Fracassi et al, 2023), stimulates inflammation/interferon signaling in different cell types (Hsu and Kao, 2018), and induces p53-dependent senescence upon oncogenic insults (Hsu and Kao, 2018).