Mass spectrometry pan-cancer proteomic data provided by the NCI Clinical Proteomic Tumor Analysis Consortium (CPTAC) (Clark et al, 2019) confirmed that the PML protein is markedly overexpressed in ccRCC (kidney renal clear-cell carcinoma; KIRC) compared to paired normal adjacent tissue (Fig. 1B). Here, PML is linked to nonpapillary renal cell carcinoma.