Although this finding may appear in contrast with published literature on PML and p53 (Liebl and Hofmann, 2022), it reflects a phenomenon that was previously described for bona fide oncogenes like c-Myc, namely that p53-dependent stress responses are triggered both by oncogene overexpression in normal cells (oncogene-induced senescence or OIS) (Zindy et al, 1998), as well as by oncogene removal in fully transformed cancer cells (oncogene inhibition-induced senescence OIIS) (Wu et al, 2007). This evidence concerns the gene TP53 and cancer.