PML was reported to sustain tumor progression via many mechanisms that include upholding cancer stem cell maintenance (Carracedo et al, 2012; Ito et al, 2008; Amodeo et al, 2017), impinging on metabolic pathways (Carracedo et al, 2012) and promoting metastasis (Ponente et al, 2017). The gene discussed is PML; the disease is cancer.