The placebo impacted pathways of Systemic lupus erythematosus, Neutrophil extracellular trap formation, and Alcoholism via upregulation of seven out of the 80 genes in H2A, H2B, H3, and H4, gene classes (H2BC21, H2BC5, H2AC16, H2BC4, H2AC8, H4C15, and H3C13) expressed in the nucleosome (GO:0,000,786; P-value (FDR) = 0.002). This evidence concerns the gene H4C15 and alcohol dependence.