Previous studies have shown that EMT signatures are associated with a unique TME of NSCLC characterized by elevated inflammatory signals, IFNγ, multiple coinhibitory and costimulatory molecule expression, and higher infiltration of CD8+ and CD4+ T-cells, Tregs, and macrophages independently of the tumor mutational burden [24, 25, 34]. The gene discussed is IFNG; the disease is non-small cell lung carcinoma.