When analyzing only the GEP-NEC subgroup, at univariate analysis, stage IV (p = 0.045), Rb1 absence of expression (p = 0.03), TP53 (p = 0.02) and APC mutations (p = 0.04) were associated with worse OS (Supplementary Figs. S6 and S7). This evidence concerns the gene APC and neuroendocrine carcinoma.