The neighboring non-coding gene Pvt1 is involved in promoting Myc expression in tumor progression19,62; however, the BAC used here does not contain the whole Pvt1 transcript and, while the sub-cluster C and D deletions affect internal Pvt1 sequences without affecting Myc expression, the sub-cluster B deletion eliminates the Pvt1 promoter and increases Myc expression in mixed-pluripotency and formative pluripotency conditions. This evidence concerns the gene PVT1 and neoplasm.