One hypothesis was that telomere shortening (HOIP:0060431) could cause type B pancreatic cell exhaustion/hypofunction of type B pancreatic cells (HOIP:0060453), resulting in positive regulation of SASP secretion (HOIP:0060455) and SASP secretion (HOIP:0060432), which might lead to insulin resistance (HOIP:0060427)26. The gene discussed is RNF31; the disease is Insulin resistance.