More specifically, we scanned 19 whole-section slide images (WSI) corresponding to three molecular subtypes of endometrial cancer (EC): (1) DNA polymerase epsilon (POLE)-mutant cases, (2) cases with mismatch repair deficiency (MMRd), and (3) cases with p53 abnormality (p53abn) as assessed by immunohistochemistry. This evidence concerns the gene POLE and mismatch repair cancer syndrome 1.