,5 YB-1 regulates the mRNA stability, transcription, and translation of a wide range of genes implicated in cancer, including c-Myc, CD44, MET, HIF1α, etc.6,7,8,9,10 Overexpression of YB-1 is associated with tumor progression, cell invasion, and the development of treatment resistance in various cancers.11 The gene discussed is HIF1A; the disease is cancer.