Moreover, anti‐tumor immune response is seriously weakened by the immunosuppressive mechanism within the tumor.[22] For instance, programmed death‐ligand 1 (PD‐L1), an immune checkpoint expressed on tumor cells, especially for colon tumor cells,[23] can bind to programmed death protein 1 (PD‐1) on T lymphocytes and then shut down the immune recognition. The gene discussed is CD274; the disease is colonic neoplasm.