CTSS and Hepatic fibrosis: The mechanism was related to the inhibition of the activation of NF-κB and its upstream molecular factor Akt.[46] Luteolin can also prevent liver fibrosis by acting on the toll-like receptor (TLR) signaling pathway to reduce extracellular matrix accumulation and cathepsin gene expression while enhancing the liver’s antioxidant system.[47] As a natural polyhydroxyflavonoid, Quercetin was widely present in nature.