The main signaling pathways included Pathways in cancer (PC), lipid and atherosclerosis (LA), AGE-RAGE signaling pathway in diabetic complications (ARPDC), proteoglycans in cancer (PRC), PI3K-Akt signaling pathway (PASP), etc (Fig. 7D and E), and more detailed enrichment results are shown in Table S8, Supplemental Digital Content, http://links.lww.com/MD/M468. The gene discussed is RENBP; the disease is cancer.