The core active components of Danhong Injection (Luteolin, Quercetin, and Kaempferol) mainly act on targets such as PTGS2, AR, ESR1, PPARG, and RELA through signal transduction of PPCPC, LA, PRC, PC, and PASP to play the role of anti-inflammatory, anti-oxidative stress, inducing apoptosis, inhibiting cell proliferation, regulating immunity, inducing DNA damage and reducing transcription factors to reduce fibronectin and collagen, inhibit extracellular matrix deposition and airway remodeling to improve IPF. This evidence concerns the gene RELA and idiopathic pulmonary fibrosis.