TM6SF2 and hepatocellular carcinoma: Grb14 knockdown in the liver, white adipose tissue, and heart using AAV-shRNA (Grb14-shRNA) improved glucose homeostasis in diet-induced obese mice.[43] The human TM6SF2 variant rs58542926 is associated with NAFLD and hepatocellular carcinoma.[44] It separates HCL from IR in recent-onset T2DM, an effect that is mitigated by the disease duration.