MFS is a systemic connective tissue disorder with a prevalence of 2 to 3/100,000 individuals.[5] Approximately 75% of individuals with MFS manifest an autosomal dominant inherited disorder resulting from a mutation in the FBN1 gene, while approximately 25% exhibit a de novo pathogenic variant or germline mosaicism of FBN1. This evidence concerns the gene FBN1 and Marfan syndrome.