PDPN and thrombocytosis disease: This formation of platelets-tumor micro-thrombocytosis could be conducive to protecting tumor cells against the mechanical shear of the blood’s circulation.[54] Meanwhile, by dynein, tumor cells uptake platelets CD42a, thus obtaining all metabolic substances by phagocytosis platelets in platelets’ cytoplasm.[55] Podoplanin is a sialylated membrane glycoprotein.