In our study, we constructed a signature consisting of 12 VRGs which was prognostic biomarker of HCC, including CYP24A1, NCOA7, TGFB1, GSR, IGFBP3, IGFBP2, VGF, AGAP2, DENND6B, LRRC8A, BCL6, FCER2. This evidence concerns the gene AGAP2 and hepatocellular carcinoma.