IGFBP3 and malignant colon neoplasm: TGFB1 was involved in the aggravation of HCC malignant behaviors.[16] IGFBP3 inhibit cell growth and insulin-like growth factor signaling in HCC.[17] LRRC8A served as a central mediator and accelerated colon cancer metastasis by regulating PIP5K1B/PIP2 pathway.[18] NCOA7 could regulates growth and metastasis of clear cell renal cell carcinoma via MAPK/ERK Signaling Pathway.[19] IGFBP3 promotes resistance to Olaparib via modulating EGFR signaling in advanced prostate cancer.[20]