In our study, we constructed a signature consisting of 12 VRGs which was prognostic biomarker of HCC, including CYP24A1, NCOA7, TGFB1, GSR, IGFBP3, IGFBP2, VGF, AGAP2, DENND6B, LRRC8A, BCL6, FCER2. Here, IGFBP3 is linked to hepatocellular carcinoma.