In our study, we constructed a signature consisting of 12 VRGs which was prognostic biomarker of HCC, including CYP24A1, NCOA7, TGFB1, GSR, IGFBP3, IGFBP2, VGF, AGAP2, DENND6B, LRRC8A, BCL6, FCER2. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.