In our study, we constructed a signature consisting of 12 VRGs which was prognostic biomarker of HCC, including CYP24A1, NCOA7, TGFB1, GSR, IGFBP3, IGFBP2, VGF, AGAP2, DENND6B, LRRC8A, BCL6, FCER2. This evidence concerns the gene IGFBP2 and hepatocellular carcinoma.