LINGO1 and essential thrombocythemia: Around one-half of ET cases are associated with genetic mutations, typically following an autosomal dominant trasmission.[35,36] Previous studies have shown Purkinje cell loss and axonal swelling in cerebellum as neurogenerative features in ET.[2–45] ET showed Recent studies have reported evidence related to Leucine-rich repeat and Ig domain containing 1 gene[37,38] and GABA receptors[37,38] in the cerebellum of ET.