Multivariable logistic regression analysis showed that smoking (OR = 5.228, 95% CI: 1.938–14.102, P = .001), coronary heart disease (OR = 4.754, 95% CI: 1.498–15.089, P = .008), and the polymorphism at PTGS1(A>G) AA/AG + GG (OR = 2.955, 95% CI: 1.320–6.616, P = .008) were independently associated with IS recurrence in Chinese patients. This evidence concerns the gene PTGS1 and coronary artery disorder.