The CDKN2C protein can bind to CDK4 or CDK6 and reduce CDK kinase activation, contributing to cell cycle arrest in the G phase.[32] In addition, studies have shown CDKN3 protein was expressed at low levels in G0/1 and S phase and was increased in M phase in parallel with phosphorylation of histone H3 Ser-10, which is a marker of M phase.[33] In our study, we found that CDCA3 is positively correlated with the expression of CDKN3, CDKN2C, CDK6, CDK4, CDK2, and CDK1 in gliomas. This evidence concerns the gene CDKN3 and central nervous system cancer.