CDK4 and central nervous system cancer: The CDKN2C protein can bind to CDK4 or CDK6 and reduce CDK kinase activation, contributing to cell cycle arrest in the G phase.[32] In addition, studies have shown CDKN3 protein was expressed at low levels in G0/1 and S phase and was increased in M phase in parallel with phosphorylation of histone H3 Ser-10, which is a marker of M phase.[33] In our study, we found that CDCA3 is positively correlated with the expression of CDKN3, CDKN2C, CDK6, CDK4, CDK2, and CDK1 in gliomas.