There has been evidence of increased CDCA3 expression in many cancer types, such as bladder tumor, NSCLC, oral cancer, as well as hepatocellular carcinoma (HCC).[11–14] In this study, we found that the upregulation of CDCA3 expression was positively correlated with the grade of glioma, and that CDCA3 expression was upregulated in gliomas with MGMT unmethylation and IDH wild-type. This evidence concerns the gene MGMT and central nervous system cancer.