TP53 and hepatocellular carcinoma: Studies have reported that MT1G can upregulate the expression of P21 and Bax by interacting with p53, leading to cell cycle arrest and apoptosis of HCC cells, respectively.[25] It has also been reported that MT1G can inhibit the proliferation and invasion of thyroid cancer and induce apoptosis.[26] Unfortunately, there are few reports about MT1G in cardiovascular diseases, and this study can make up for this.