Nowadays, the utilization of bioinformatics analyses and machine learning algorithms to discover novel gene prognostic signatures is a prominent area of research.[42] Within the context of breast cancer, numerous prognostic measures and treatments rely on the expression of pivotal genes, with ER, PR, and HER2 serving as the most employed indicators in clinical practice.[43] The treatment of breast cancer has evolved from a singular surgical intervention to personalized adjuvant therapy, such as chemoradiotherapy.[44–46]. This evidence concerns the gene ESR1 and breast carcinoma.