VCAN and obesity due to melanocortin 4 receptor deficiency: Fas cell surface death receptor (Fas), versican (Vcan), T-box transcription factor 21 (Tbx21), angiotensin I converting enzyme (Ace), and serpin family E member 2 (Serpine2), metabolic markers associated with obesity (30–35), were increased in the obese group (Fig. 1D).