One month after infection, pyridoxine moderately reduced TNF-α and IL-6 levels (Fig 6G), reduced the number of CD11c+CD11b+ and CD11c+F4/80+ cells (S6A Fig), reduced RIPK3 and MLKL mRNA expression, had no difference in bacterial burden and TNFR1 in lungs of PBS treated Mtb-infected T2DM mice (Figs 6E, 6F, 6H and S5B). This evidence concerns the gene TNFRSF1A and type 2 diabetes mellitus.