Meanwhile, the above five pathways related to the diseases of the musculoskeletal system and connective tissue contain more enriched genes identified by ceCLC in NET than the enriched genes identified in N.O. For example, 43 SNPs within six mapped genes identified by ceCLC in N.O. are enriched in rheumatoid arthritis pathway, including ATP6V1G2, HLA-DRA, LTB, TNF, HLA-DRB1, and HLA-DQA1; and 111 SNPs within 12 mapped genes in NET are enriched in this pathway, including HLA-DMA, HLA-DMB, ATP6V1G2, HLA-DRA, LTB, HLA-DOA, TNF, HLA-DOB, HLA-DQA2, HLA-DRB1, HLA-DQA1, and HLA-DQB1. The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.