The present results agreed with previously published data that refer the role of PTGS2 (known as cyclooxygenase-2) to have a protective role against gastric ulcer, their inhibitors delay the gastric ulcer healing, The enhanced level of COX-2 mRNA and protein near the ulcer border is spatially and temporally associated with increased the proliferation of epithelial cell and heightened expression of growth factors. The gene discussed is PTGS2; the disease is gastric ulcer.