The importance of this process in PINK1/Parkin-associated PD has led to an intense focus on understanding the regulation of PINK1 and Parkin (Themistokleous et al., 2023), as well as the events of mitophagy initiation that occur immediately downstream of PINK1 and Parkin (Uoselis et al., 2023). Here, PRKN is linked to Parkinson disease.