(A) AAV8-RO1.7-Hsp90ab1-FLAG (1×109 vg/eye) co-injected with shNC (non-targeting shRNA control, AAV8-RedO-shRNA, 1×109 vg/eye) or co-injected with Hsp90ab1 shRNAs #a, #b, #c (AAV8-RedO-shRNA, 1×109 vg/eye) in P20 wild-type (wt) retina, all also injected with AAV8-RedO-H2BGFP (2.5×108 vg/eye) to track the infection. Here, HSP90AB1 is linked to infection.