Moreover, patients with DM2 and periodontitis show elevated levels of interleukin (IL)-10, while the concentration of IL-4 in diabetic subjects with periodontitis is low compared to non-diabetic patients with periodontitis, showing that there is a correlation between the level of these markers and the impairment of the immune response of patients with periodontitis and DM2. This evidence concerns the gene IL10 and periodontitis.