In our studies, we showed that the infusion of Ang II by pharmacologically implanting osmotic pumps in immune-competent C57BL/6 mice (without tumor), followed by treatment with WFA, showed a significant reduction/reversal in Ang II-induced cardiac remodeling and dysfunctions (systolic and diastolic), likely due to the targeting of multi-pathways, demonstrating a direct anticachectic effect of WFA on the heart (Figure 10). This evidence concerns the gene AGT and neoplasm.