In the present study with the continual infusion of Ang II for 4 weeks, the general features of cardiac cachexia were determined to show a significant decrease in cardiac functions (Figure 1, Figure 2 and Figure 3), structural remodeling, including increased MHCβ mRNA expression levels (Figure 4), and myocardial fibrosis (Figure 6), confirming the success of this model and mimicking the cancer-induced cardiac cachexia model. Here, AGT is linked to Myocardial fibrosis.