The stemness gene Kruppel-like factor 4 (KLF4) is also upregulated by CD133 in this NF-κB pathway (Figure 3B), in agreement with our previous results showing upregulation of other stemness genes such as Oct4 and ABCB5 in CD133(+)-enriched BAKP melanoma stem cells [18]. The gene discussed is POU5F1; the disease is melanoma.