Mice overexpressing BMP4 in adipocytes from the FABP4/aP2 promoter showed reduced sWAT mass and adipocyte size along with an increased number of white adipocytes with brown characteristics, increased energy expenditure, improved insulin sensitivity and glucose tolerance, and protection against HFD-induced obesity and metabolic derangement [108]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.