CD8A and congenital secretory chloride diarrhea 1: However, considering previous reports that CD8 T cells play a protective role during hepatic injury resolution by eliminating activated HSCs [42], and their dysfunction at the advanced stages of CLD exacerbate disease progression [43,44], further comprehensive investigations are needed to understand the specific functions of different CD8 T cell subsets in promoting and regressing hepatic fibrosis in CLD.