Pharmacological inhibition of caspases 8 and 3 rescued cancer cells from siα3-mediated killing, as shown by a reduction in their cleavage and activity (Figure 3E,F and Supplementary Figure S2E,F), as well as downstream PARP processing (Figure 3E and Supplementary Figure S2F), and cell viability increase (Figure 3G). This evidence concerns the gene CASP8 and cancer.