mRNA assessment of bone markers for different stages of osteogenesis and pro-fibrotic markers presented increased early-stage osteogenic markers osterix (OSX), distal-less homeobox 5 (DLX5), and alkaline phosphatase (ALPL), and significantly decreased late-stage markers dentin matrix acidic phosphoprotein 1 (DMP1) and sclerostin (SOST), along with a marked rise in pro-fibrotic markers COL1A1, TGF-β1, PLOD2, interluekin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α), which were highly correlative to the expression patterns observed in parent FD tissues. This evidence concerns the gene COL1A1 and Fabry disease.