CAR-T-cells lacking all three NR4A transcription factors display increased cytokine production, gene expression associated with effector CD8+ cells, and increased survival and tumor regression in tumor-bearing mice, with chromatin motifs exhibiting enhanced binding at nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and AP-1 sites [169]. The gene discussed is CD8A; the disease is neoplasm.