EGFR and neoplasm: In this trial on the efficacy of CAR-TEAM cells against GBM, EGFRvIII-targeting CAR-T cells were engineered to secrete TEAMs targeting the wild-type EGFR receptor, as antigen loss in tumors treated with EGFRvIII CAR alone is correlated with tumor persistence and amplification of wild-type EGFR surface expression [188,189].